The Avchala Stadium in Tbilisi will be bouncing for the game at 4pm local time (noon UTC) as the sides look to make it three wins from three before the knock-out stages.
Both sides have nine points from a possible 10 and Georgia are just currently top on points difference as +32 plays +24.
Georgia won the corresponding fixture last year 41-3 and are 13th in the world rankings with Spain 19th.
Next up at 4.30pm local time (2,30pm UTC) is the Pool B decider between current leaders Romania and Portugal.
Romania are on nine points with Portugal on six, they are 20th and 16th in the world respectively and when they met in this tournament last year the Portuguese side won 38-10.
The match is being played in the Arcul de Triumf stadium in Bucharest.
The third match on Saturday sees Belgium and Poland meeting at 6pm local time (5pm UTC) at the Stade du Pachy in Waterloo.
This is a Pool B match and Belgium are third in the standings with four points and Poland are fourth and yet to get off the mark.
There are sitting 26th and 33rd in the world respectively and Poland won the group stage match between the two 21-15 last year before the Belgians got revenge in the play-off phase 18-17 to finish seventh.
Sunday sees the final group game being played and the full knock-out phase being finalised.
It is Netherlands against Germany and they are currently third and fourth in Pool A.
The clash takes place at the National Rugby Center in Amsterdam at 1.30pm local time (12.30pm UTC) and is 29th in the world versus 32nd.
Netherlands won 33-29 in the corresponding fixture last year and then won the play-off meeting 50-28 to finish fifth.
